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recombinant human serpine2  (Proteintech)


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    Proteintech recombinant human serpine2
    Recombinant Human Serpine2, supplied by Proteintech, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/recombinant+human+serpine2/serpina5+antibody+10673+1+ap/pm27876880-201-32-35
    Average 90 stars, based on 1 article reviews
    recombinant human serpine2 - by Bioz Stars, 2026-10
    90/100 stars

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    Recombinant:

    Article Title: Overexpression of SerpinE2/protease nexin-1 Contribute to Pathological Cardiac Fibrosis via increasing Collagen Deposition.
    Article Snippet: .. After starvation in serum-free medium for 24 h, 50 nM AngII (Sigma– Aldrich, St. Louis, MO, USA), or 10 ng/ml recombinant human TGF-β 1 protein (Sino Biological Inc., China), or 10 ng/ml recombinant human serpinE2 (Proteintech Inc., USA) were applied to cardiac fibroblasts, respectively, for 24 h and 48 h. Transfection shRNA SerpinE2, siRNA ERK-1 or siRNA Elk1. .. For transfection, cardiac fibroblasts were cultured with serum-free medium once and then incubated with serum-free medium for 6 h. The shRNA serpinE2 (PN-1 shRNA Plasmid (h): sc-45254-SH Santa Cruz Biotechnology Inc., USA), siRNA ERK-1 and siRNA Elk1 (Guangzhou RiboBio Co. Ltd., China), and X-treme GENE siRNA Transfection Reagent (Roche, USA) were mixed, respectively, with Opti-MEM® Reduced Serum Medium (Gibco, Grand Island, NY), and then cardiac fibroblast were treated with each mix for transfection, according to the manufacturer’s protocol.

    Article Title: Overexpression of SerpinE2/protease nexin-1 Contribute to Pathological Cardiac Fibrosis via increasing Collagen Deposition
    Article Snippet: .. After starvation in serum-free medium for 24 h, 50 nM AngII (Sigma–Aldrich, St. Louis, MO, USA), or 10 ng/ml recombinant human TGF-β1 protein (Sino Biological Inc., China), or 10 ng/ml recombinant human serpinE2 (Proteintech Inc., USA) were applied to cardiac fibroblasts, respectively, for 24 h and 48 h. .. For transfection, cardiac fibroblasts were cultured with serum-free medium once and then incubated with serum-free medium for 6 h. The shRNA serpinE2 (PN-1 shRNA Plasmid (h): sc-45254-SH Santa Cruz Biotechnology Inc., USA), siRNA ERK-1 and siRNA Elk1 (Guangzhou RiboBio Co. Ltd., China), and X-treme GENE siRNA Transfection Reagent (Roche, USA) were mixed, respectively, with Opti-MEM ® Reduced Serum Medium (Gibco, Grand Island, NY), and then cardiac fibroblast were treated with each mix for transfection, according to the manufacturer’s protocol.

    Transfection:

    Article Title: Overexpression of SerpinE2/protease nexin-1 Contribute to Pathological Cardiac Fibrosis via increasing Collagen Deposition.
    Article Snippet: .. After starvation in serum-free medium for 24 h, 50 nM AngII (Sigma– Aldrich, St. Louis, MO, USA), or 10 ng/ml recombinant human TGF-β 1 protein (Sino Biological Inc., China), or 10 ng/ml recombinant human serpinE2 (Proteintech Inc., USA) were applied to cardiac fibroblasts, respectively, for 24 h and 48 h. Transfection shRNA SerpinE2, siRNA ERK-1 or siRNA Elk1. .. For transfection, cardiac fibroblasts were cultured with serum-free medium once and then incubated with serum-free medium for 6 h. The shRNA serpinE2 (PN-1 shRNA Plasmid (h): sc-45254-SH Santa Cruz Biotechnology Inc., USA), siRNA ERK-1 and siRNA Elk1 (Guangzhou RiboBio Co. Ltd., China), and X-treme GENE siRNA Transfection Reagent (Roche, USA) were mixed, respectively, with Opti-MEM® Reduced Serum Medium (Gibco, Grand Island, NY), and then cardiac fibroblast were treated with each mix for transfection, according to the manufacturer’s protocol.

    shRNA:

    Article Title: Overexpression of SerpinE2/protease nexin-1 Contribute to Pathological Cardiac Fibrosis via increasing Collagen Deposition.
    Article Snippet: .. After starvation in serum-free medium for 24 h, 50 nM AngII (Sigma– Aldrich, St. Louis, MO, USA), or 10 ng/ml recombinant human TGF-β 1 protein (Sino Biological Inc., China), or 10 ng/ml recombinant human serpinE2 (Proteintech Inc., USA) were applied to cardiac fibroblasts, respectively, for 24 h and 48 h. Transfection shRNA SerpinE2, siRNA ERK-1 or siRNA Elk1. .. For transfection, cardiac fibroblasts were cultured with serum-free medium once and then incubated with serum-free medium for 6 h. The shRNA serpinE2 (PN-1 shRNA Plasmid (h): sc-45254-SH Santa Cruz Biotechnology Inc., USA), siRNA ERK-1 and siRNA Elk1 (Guangzhou RiboBio Co. Ltd., China), and X-treme GENE siRNA Transfection Reagent (Roche, USA) were mixed, respectively, with Opti-MEM® Reduced Serum Medium (Gibco, Grand Island, NY), and then cardiac fibroblast were treated with each mix for transfection, according to the manufacturer’s protocol.



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    <t>SERPINE2</t> expression is significantly upregulated in COAD. (A) Box plot of SERPINE family genes mRNA expression.in COAD(p < 0.05). (B) Box plot of SERPINE1 and SERPINE2 protein expression in COAD(p < 0.05). (C) Box plot of SERPINE2 mRNA expression among groups of different tumor grades in COAD (p < 0.05).
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    Image Search Results


    SERPINE2 expression is significantly upregulated in COAD. (A) Box plot of SERPINE family genes mRNA expression.in COAD(p < 0.05). (B) Box plot of SERPINE1 and SERPINE2 protein expression in COAD(p < 0.05). (C) Box plot of SERPINE2 mRNA expression among groups of different tumor grades in COAD (p < 0.05).

    Journal: Frontiers in Oncology

    Article Title: SerpinE2 promotes M2 polarization in macrophage to accelerate colorectal cancer progression

    doi: 10.3389/fonc.2025.1585935

    Figure Lengend Snippet: SERPINE2 expression is significantly upregulated in COAD. (A) Box plot of SERPINE family genes mRNA expression.in COAD(p < 0.05). (B) Box plot of SERPINE1 and SERPINE2 protein expression in COAD(p < 0.05). (C) Box plot of SERPINE2 mRNA expression among groups of different tumor grades in COAD (p < 0.05).

    Article Snippet: Besides, in order to explore the effect of SERPINE2 on macrophage polarization, M0 macrophages were treated with recombinant SERPINE2 (0.4 ng/mL, TargetMol) during 24 hours and then harvested for subsequent experiment.

    Techniques: Expressing

    SERPINE2 expression correlates with tumor immunoregulation, division and proliferation. (A) Volcano map of SERPINE2 co-expressed genes in COAD. (B, C) GO and KEGG enrichment analysis of SERPINE2 co-expressed genes obtained from the cBioPortal, the terms p and q < 0.05 were considered to be significantly enriched. Only 20 leading gene sets are displayed in the plot.

    Journal: Frontiers in Oncology

    Article Title: SerpinE2 promotes M2 polarization in macrophage to accelerate colorectal cancer progression

    doi: 10.3389/fonc.2025.1585935

    Figure Lengend Snippet: SERPINE2 expression correlates with tumor immunoregulation, division and proliferation. (A) Volcano map of SERPINE2 co-expressed genes in COAD. (B, C) GO and KEGG enrichment analysis of SERPINE2 co-expressed genes obtained from the cBioPortal, the terms p and q < 0.05 were considered to be significantly enriched. Only 20 leading gene sets are displayed in the plot.

    Article Snippet: Besides, in order to explore the effect of SERPINE2 on macrophage polarization, M0 macrophages were treated with recombinant SERPINE2 (0.4 ng/mL, TargetMol) during 24 hours and then harvested for subsequent experiment.

    Techniques: Expressing

    SERPINE2 is positively correlated with M2 macrophage infiltration in COAD. (A) Scatter plot showing the correlation of 6 different immune cell types and SERPINE2 expression (p < 0.05). The black line in each plot is a fitted linear model indicating the proportion of tropism of the immune cell along with SERPINE2 expression, and the Pearson coefficient was used for the correlation test. (B) Scatter plot showing the correlation of CD68+ Marcophage and SERPINE2 expression (p < 0.05). C.Scatter plot showing the correlation of M1/M2 macrophage and SERPINE2 expression (p < 0.05). The blue line in each plot is a fitted linear model indicating the proportion of tropism of the immune cell along with SERPINE2 expression, and the Pearson coefficient was used for the correlation test. (p < 0.05).

    Journal: Frontiers in Oncology

    Article Title: SerpinE2 promotes M2 polarization in macrophage to accelerate colorectal cancer progression

    doi: 10.3389/fonc.2025.1585935

    Figure Lengend Snippet: SERPINE2 is positively correlated with M2 macrophage infiltration in COAD. (A) Scatter plot showing the correlation of 6 different immune cell types and SERPINE2 expression (p < 0.05). The black line in each plot is a fitted linear model indicating the proportion of tropism of the immune cell along with SERPINE2 expression, and the Pearson coefficient was used for the correlation test. (B) Scatter plot showing the correlation of CD68+ Marcophage and SERPINE2 expression (p < 0.05). C.Scatter plot showing the correlation of M1/M2 macrophage and SERPINE2 expression (p < 0.05). The blue line in each plot is a fitted linear model indicating the proportion of tropism of the immune cell along with SERPINE2 expression, and the Pearson coefficient was used for the correlation test. (p < 0.05).

    Article Snippet: Besides, in order to explore the effect of SERPINE2 on macrophage polarization, M0 macrophages were treated with recombinant SERPINE2 (0.4 ng/mL, TargetMol) during 24 hours and then harvested for subsequent experiment.

    Techniques: Expressing

    SERPINE2 is associated with infiltration of CD68 macrophage in COAD patients. (A) The expression of SEPRINE2 in patient tissues was detected by IHC. Adjacent tissue not expressing SERPINE2; tumor tissue strongly expressing SERPINE2. (B) Scatterplot showing the correlation between SERPINE2 and CD68 expression (p < 0.05). The blue line in each plot is a fitted linear model indicating the relationship between SERPINE2 and CD68 expression. (C) The expression of SERPINE2 and CD68 in patient tissues were detected by IHC. High levels of SERPINE2 expression are associated with increased expression of CD68. (* p<0.05, **p<0.01, *** p<0.001).

    Journal: Frontiers in Oncology

    Article Title: SerpinE2 promotes M2 polarization in macrophage to accelerate colorectal cancer progression

    doi: 10.3389/fonc.2025.1585935

    Figure Lengend Snippet: SERPINE2 is associated with infiltration of CD68 macrophage in COAD patients. (A) The expression of SEPRINE2 in patient tissues was detected by IHC. Adjacent tissue not expressing SERPINE2; tumor tissue strongly expressing SERPINE2. (B) Scatterplot showing the correlation between SERPINE2 and CD68 expression (p < 0.05). The blue line in each plot is a fitted linear model indicating the relationship between SERPINE2 and CD68 expression. (C) The expression of SERPINE2 and CD68 in patient tissues were detected by IHC. High levels of SERPINE2 expression are associated with increased expression of CD68. (* p<0.05, **p<0.01, *** p<0.001).

    Article Snippet: Besides, in order to explore the effect of SERPINE2 on macrophage polarization, M0 macrophages were treated with recombinant SERPINE2 (0.4 ng/mL, TargetMol) during 24 hours and then harvested for subsequent experiment.

    Techniques: Expressing

    The external secretion of SERPINE2 from colorectal cancer cells promotes macrophage polarization to accelerate the development of colorectal cancer. (A) Schema diagram showing that THP-1 cells were treated with PMA, followed by the treatment of SERPINE2 recombinant protein as indicated treatments to obtain activated macrophages. Then tumor cells cocultured with these macrophages. were used to subsequent experiments. (B, C) RT-qPCR and Westen blot displayed SERPINE2 mRNA and Protein expression were upregulated in colorectal cancer cells. (D) The secretion of SERPINE2 in colorectal cancer cells was detected by ELISA. (E) The effect of SERPINE2 recombinant protein on macrophage polarization. (F) RT-qPCR displayed conditioned medium (CM) derived from colorectal cancer cells promotes the upregulation of macrophage M2 markers, compared to normal Intestinal cells. (G) ELISA analysis demonstrated that SERPINE2 secretion was significantly reduced after SERPINE2 knockdown. (H) RT-qPCR displayed conditioned medium with SERPINE2 knockdown down-regulated macrophage M2 markers. (I, J) The conditioned medium from macrophages treated with SERPINE2 recombinant protein promoted cancer cell proliferation (measured by CCK-8 assay) and migration (assessed by Transwell assay. (*p<0.05, **p<0.01, ***p<0.001).

    Journal: Frontiers in Oncology

    Article Title: SerpinE2 promotes M2 polarization in macrophage to accelerate colorectal cancer progression

    doi: 10.3389/fonc.2025.1585935

    Figure Lengend Snippet: The external secretion of SERPINE2 from colorectal cancer cells promotes macrophage polarization to accelerate the development of colorectal cancer. (A) Schema diagram showing that THP-1 cells were treated with PMA, followed by the treatment of SERPINE2 recombinant protein as indicated treatments to obtain activated macrophages. Then tumor cells cocultured with these macrophages. were used to subsequent experiments. (B, C) RT-qPCR and Westen blot displayed SERPINE2 mRNA and Protein expression were upregulated in colorectal cancer cells. (D) The secretion of SERPINE2 in colorectal cancer cells was detected by ELISA. (E) The effect of SERPINE2 recombinant protein on macrophage polarization. (F) RT-qPCR displayed conditioned medium (CM) derived from colorectal cancer cells promotes the upregulation of macrophage M2 markers, compared to normal Intestinal cells. (G) ELISA analysis demonstrated that SERPINE2 secretion was significantly reduced after SERPINE2 knockdown. (H) RT-qPCR displayed conditioned medium with SERPINE2 knockdown down-regulated macrophage M2 markers. (I, J) The conditioned medium from macrophages treated with SERPINE2 recombinant protein promoted cancer cell proliferation (measured by CCK-8 assay) and migration (assessed by Transwell assay. (*p<0.05, **p<0.01, ***p<0.001).

    Article Snippet: Besides, in order to explore the effect of SERPINE2 on macrophage polarization, M0 macrophages were treated with recombinant SERPINE2 (0.4 ng/mL, TargetMol) during 24 hours and then harvested for subsequent experiment.

    Techniques: Recombinant, Quantitative RT-PCR, Expressing, Enzyme-linked Immunosorbent Assay, Derivative Assay, Knockdown, CCK-8 Assay, Migration, Transwell Assay